Port 5080 is used by the 3CX Tunnel service for internal communication with other services. That said, the message you observed may be unrelated to the issue you are experiencing so I'd suggest we first try to narrow it down by collecting additional information.
That said, please first provide the relevant information mentioned here:
https://www.3cx.com/community/threads/information-to-provide-when-requesting-help.67558/
Also:
• Is this issue always affecting the same users?
• If not, does it happen to always affect the same type of 3CX endpoints such as IP Phones behind an SBC, 3CX mobile clients, 3CX Windows clients, etc.
• You say that the call gets interrupted after a while, is the duration of the call always the same before it gets cut off?
• Does the call actually drop or do you simply stop getting audio with the IP Phone/3CX Client still showing that the call is in progress?
Note: 3CX endpoints that use the 3CX Tunnel are the following: 3CX Windows client(when remote), IP Phones behind an SBC, 3CX mobile clients(iOS and Android), bridged 3CX PBX with tunnel enabled. If the affected calls do not involve any of the above, then it is most likely that the message you observed is indeed irrelevant.